Dietary and pharmacological energy restriction and exercise for healthspan extension
Extending healthspan - the years lived in optimal health - holds transformative potential to reduce chronic diseases and healthcare costs. Dietary restriction (DR), particularly when combined with nutrient-rich diets and exercise, is among the mos...
Cagigas ML, De Ciutiis I, Masedunskas A et al. — Trends in endocrinology and metabolism: TEM
The impact of inactivation of the GH/IGF axis during aging on healthspan
Several mouse lines with congenital growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis disruption have shown improved health and extended lifespan. The current study investigated how inactivating this axis, specifically during aging, im...
Poudel SB, Ruff RR, He Z et al. — GeroScience
The Effects of Metformin on Weight Loss, Cardiovascular Health, and Longevity
Metformin, a biguanide derived from Galega officinalis, was first synthesized by Werner and Bell in 1922. Metformin was approved for the treatment of diabetes by the US Food and Drug Administration in 1994. It has since become the most widely used...
Pillai AA, Melo L, Frishman WH et al. — Cardiology in review
Somatic growth, aging, and longevity
Although larger species of animals typically live longer than smaller species, the relationship of body size to longevity within a species is generally opposite. The longevity advantage of smaller individuals can be considerable and is best docume...
Bartke A — NPJ aging and mechanisms of disease
Growth Hormone Deficiency: Health and Longevity
The important role of GH in the control of mammalian longevity was first deduced from extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with isolated GHD (IGHD) due to GHRH or GHRH receptor mutations, combined defi...
Aguiar-Oliveira MH, Bartke A — Endocrine reviews
Growth signaling and longevity in mouse models
Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting g...
Kim SS, Lee CK — BMB reports
Can FSH influence longevity?
It was recently reported that the extragonadal actions of follicle-stimulating hormone (FSH) include regulation of brown and white adipose tissue function and thermogenesis. Based on these findings and on our evidence for reduced FSH levels and en...
Bartke A — Aging cell
Healthspan and longevity can be extended by suppression of growth hormone signaling
Average and maximal lifespan are important biological characteristics of every species, but can be modified by mutations and by a variety of genetic, dietary, environmental, and pharmacological interventions. Mutations or disruption of genes requi...
Bartke A — Mammalian genome : official journal of the International Mammalian Genome Society
The somatotropic axis and longevity in mice
The somatotropic signaling pathway has been implicated in aging and longevity studies in mice and other species. The physiology and lifespans of a variety of mutant mice, both spontaneous and genetically engineered, have contributed to our current...
Brown-Borg HM — American journal of physiology. Endocrinology and metabolism
The GH/IGF-1 axis in ageing and longevity
Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This phenomenon, which is known as the 'somatopause', h...
Junnila RK, List EO, Berryman DE et al. — Nature reviews. Endocrinology
Longevity genes: insights from calorie restriction and genetic longevity models
In this review, we discuss the genes and the related signal pathways that regulate aging and longevity by reviewing recent findings of genetic longevity models in rodents in reference to findings with lower organisms. We also paid special attentio...
Shimokawa I, Chiba T, Yamaza H et al. — Molecules and cells
Igf-I and longevity
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan...
Janssen JA, Lamberts SW — Hormone research