A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity...
Marotti V, Xu Y, Bohns Michalowski C et al. — Bioactive materials
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endoge...
Sung J, Ju SY, Park S et al. — Tissue & cell
Omega-3 Supplementation and Its Effects on Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by the destruction of the articular cartilage, resulting in a pro-inflammatory response. The progression of OA is multifactorial and is influenced by the underlying cause of inflamm...
Shawl M, Geetha T, Burnett D et al. — Nutrients
Omega-3-fatty acids: Do they prevent cardiovascular disease?
Despite cardiovascular disease (CVD) reductions with high-intensity statins, there remains residual risk among patients with metabolic disorders. Alongside low-density lipoproteins (LDL-C), elevated triglycerides (TG) are associated with incident ...
Mason RP, Sherratt SCR, Eckel RH — Best practice & research. Clinical endocrinology & metabolism
Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H2O2-Induced Vitiligo Mouse Model
Extremely limited drug retention and depigmentation represent the greatest barriers against vitiligo treatment advancement. Here, inspired by biological melanosomes, the primary melanin transporter, we developed biomimetic melanosomes to combat re...
Sun MC, Xu XL, Du Y et al. — ACS nano
Efficacy of omega-3 PUFAs in depression: A meta-analysis
We conducted this meta-analysis of double-blind randomized placebo-controlled trials to estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in the improvement...
Liao Y, Xie B, Zhang H et al. — Translational psychiatry
Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin
Lysine-proline-valine (KPV) is a C-terminal peptide fragment of α-melanocyte stimulating hormone with potent anti-inflammatory properties. Present study investigates various transdermal enhancement strategies such as iontophoresis (ITP), mic...
Pawar K, Kolli CS, Rangari VK et al. — Journal of pharmaceutical sciences
Peptide Receptor-Targeted Fluorescent Probe: Visualization and Discrimination between Chronic and Acute Ulcerative Colitis
The inflammatory activity of ulcerative colitis plays an important role in the medical treatment. However, accurate and real-time monitoring of the colitis activity with noninvasive bioimaging method is still challenging, especially in distinguish...
Zeng M, Shao A, Li H et al. — ACS applied materials & interfaces
Omega-3 fatty acids and inflammatory processes: from molecules to man
Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspec...
Calder PC — Biochemical Society transactions
Impact of Omega-3 Fatty Acids on the Gut Microbiota
Long-term dietary habits play a crucial role in creating a host-specific gut microbiota community in humans. Despite the many publications about the effects of carbohydrates (prebiotic fibers), the impact of dietary fats, such as omega-3 polyunsat...
Costantini L, Molinari R, Farinon B et al. — International journal of molecular sciences
Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates
A simple, sensitive and stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for a bioactive peptide, lysine-proline-valine (KPV) in aqueous solutions and skin homogenates. Chromatographic se...
Pawar KR, Mulabagal V, Smith F et al. — Biomedical chromatography : BMC
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
Inflammation is a condition which contributes to a range of human diseases. It involves a multitude of cell types, chemical mediators, and interactions. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are omega-3 (n-3) fatty acids found...
Calder PC — Biochimica et biophysica acta
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of aspects of inflammation including leucocyte chemotaxis, adhesion m...
Calder PC — British journal of clinical pharmacology
Omega-3 fatty acids and inflammatory processes
Long chain fatty acids influence inflammation through a variety of mechanisms; many of these are mediated by, or at least associated with, changes in fatty acid composition of cell membranes. Changes in these compositions can modify membrane fluid...
Calder PC — Nutrients
Omega-3 fatty acids EPA and DHA: health benefits throughout life
Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life. Recently, fish-derived omega-3 fatty acids EPA and DHA have been associated with fetal development, cardiovascular function, and Alzheimer's disease. However, because o...
Swanson D, Block R, Mousa SA — Advances in nutrition (Bethesda, Md.)
Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Despite some progress in recent years, the options for treating inflammatory bowel disease (IBD) are still dissatisfying, and surgery rates are still high. The anti-inflammatory effects of melanocortin peptides such as alpha-melanocyte-stimulating...
Kannengiesser K, Maaser C, Heidemann J et al. — Inflammatory bowel diseases
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells
alpha-MSH signals by binding to the melanocortin-1 receptor (MC-1R) and elevating cyclic AMP in several different cells. The anti-inflammatory properties of this peptide are also believed to be cyclic AMP dependent. The carboxyl terminal tripeptid...
Elliott RJ, Szabo M, Wagner MJ et al. — The Journal of investigative dermatology
Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
In this study, we analyzed the anti-inflammatory effects of alpha-melanocyte stimulating hormone (MSH)11-13 (KPV) in comparison with other MSH peptides in a model of crystal-induced peritonitis. Systemic treatment of mice with KPV, alpha-MSH, the ...
Getting SJ, Schiöth HB, Perretti M — The Journal of pharmacology and experimental therapeutics
New insights into the functions of alpha-MSH and related peptides in the immune system
There is a substantial body of evidence that the tridecapeptide alpha-melanocyte-stimulating hormone (alpha-MSH) functions as a mediator of immunity and inflammation. The immunomodulating capacity of alpha-MSH is primarily because of its effects o...
Luger TA, Scholzen TE, Brzoska T et al. — Annals of the New York Academy of Sciences
Omega-3 fatty acids in inflammation and autoimmune diseases
Among the fatty acids, it is the omega-3 polyunsaturated fatty acids (PUFA) which possess the most potent immunomodulatory activities, and among the omega-3 PUFA, those from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--are ...
Simopoulos AP — Journal of the American College of Nutrition