Technology behind augmenting fracture healing
Despite bone's robust regenerative capacity, complications such as delayed union and nonunion affect 5-10% of fractures, with significant clinical and economic burdens. The rising incidence of fractures, particularly in an aging population, highli...
Mehta D, Leucht P — Bulletin of the Hospital for Joint Disease (2013)
Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing
The pain associated with bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration. To characterize neuroanatomical circuitry mediating skeletal nociception and regeneration, we profiled dor...
Xu M, Li Z, Thottappillil N et al. — Science (New York, N.Y.)
Accelerated Bone Healing via Electrical Stimulation
Piezoelectric effect produces an electrical signal when stress is applied to the bone. When the integrity of the bone is destroyed, the biopotential within the defect site is reduced and several physiological responses are initiated to facilitate ...
Sun J, Xie W, Wu Y et al. — Advanced science (Weinheim, Baden-Wurttemberg, Germany)
PDGF inhibits BMP2-induced bone healing
Bone regeneration depends on a pool of bone/cartilage stem/progenitor cells and signaling mechanisms regulating their differentiation. Using in vitro approach, we have shown that PDGF signaling through PDGFRβ inhibits BMP2-induced osteogenes...
Novak S, Madunic J, Shum L et al. — NPJ Regenerative medicine
Irisin promotes fracture healing by improving osteogenesis and angiogenesis
Osteogenesis and angiogenesis are important for bone fracture healing. Irisin is a muscle-derived monokine that is associated with bone formation.
Kan T, He Z, Du J et al. — Journal of orthopaedic translation
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing
The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in fracture healing is not yet well characterized. In this study, we first de...
Liu Y, Tian H, Hu Y et al. — International journal of biological sciences
MicroRNAs and fracture healing: Pre-clinical studies
During the past several years, pre-clinical experiments have established that microRNAs (miRNAs), small non-coding RNAs, serve as key regulatory molecules of fracture healing. Their easy modulation with agonists and antagonists make them highly de...
Komatsu DE, Duque E, Hadjiargyrou M — Bone
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors
Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows that after TBI, injured neurons, mainly those in the hippocampus, release osteogeni...
Xia W, Xie J, Cai Z et al. — Nature communications
Orthobiologics for Bone Healing
Orthobiologics are a group of biological materials and substrates that promote bone, ligament, muscle, and tendon healing. These substances include bone autograft, bone allograft, demineralized bone matrix, bone graft substitutes, bone marrow aspi...
Calcei JG, Rodeo SA — Clinics in sports medicine
Muscle-bone interactions during fracture healing
Although it is generally accepted that the rate and strength of fracture healing is intimately linked to the integrity of surrounding soft tissues, the contribution of muscle has largely been viewed as a vascular supply for oxygen and nutrient exc...
Davis KM, Griffin KS, Chu TG et al. — Journal of musculoskeletal & neuronal interactions