Emerging Strategies in Cartilage Repair and Joint Preservation
Background and Objectives: Cartilage repair remains a critical challenge in orthopaedic medicine due to the tissue's limited self-healing ability, contributing to degenerative joint conditions such as osteoarthritis (OA). In response, regenerative...
Focsa MA, Florescu S, Gogulescu A — Medicina (Kaunas, Lithuania)
Orthobiologics for Cartilage Repair
Orthobiologics are substances derived from biological sources and are increasingly used in cartilage repair. Mesenchymal signaling cells (MSCs) play a crucial role in cartilage regeneration, but face challenges in clinical application. Platelet-ri...
Mufti YN, Sachs JP, Bi AS et al. — Clinics in sports medicine
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor
Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, mini...
Shen C, Wang J, Li G et al. — Bioactive materials
Latest Advances in Chondrocyte-Based Cartilage Repair
Chondrocyte-based cell therapy has been used for more than 30 years and is still considered to be a promising method of cartilage repair despite some limitations. This review introduces the latest developments of four generations of autologous cho...
Yue L, Lim R, Owens BD — Biomedicines
Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration
Purpose: Chondrocytes (CHs) in cartilage undergo several detrimental events during the development of osteoarthritis (OA). However, the mechanism underlying CHs regeneration involved in pathogenesis is largely unknown. The aim of this study was to...
Li J, Fan C, Lv Z et al. — Theranostics
Cell therapy for cartilage repair
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translati...
Hulme CH, Perry J, McCarthy HS et al. — Emerging topics in life sciences
WNT3A-loaded exosomes enable cartilage repair
Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits its penetration and signalling to chondrocytes. Extracellular v...
Thomas BL, Eldridge SE, Nosrati B et al. — Journal of extracellular vesicles
Cellular therapy and tissue engineering for cartilage repair
Articular cartilage (AC) has limited capacity for repair. The first attempt to repair cartilage using tissue engineering was reported in 1977. Since then, cell-based interventions have entered clinical practice in orthopaedics, and several tissue ...
Zelinka A, Roelofs AJ, Kandel RA et al. — Osteoarthritis and cartilage
Platelet-Rich Plasma and Cartilage Repair
To assess the utilization and efficacy of platelet-rich plasma (PRP), for the treatment of articular cartilage injury, most commonly characterized by progressive pain and loss of joint function in the setting of osteoarthritis (OA).
Kennedy MI, Whitney K, Evans T et al. — Current reviews in musculoskeletal medicine
Animal models for cartilage repair
Cartilage lesions still represent an unsolved problem: despite the efforts of the basic and translational research, the regeneration of this tissue is far from being reached (1-3). Articular cartilage lesions can be divided in two main groups: sup...
Tessaro I, Nguyen VT, Di Giancamillo A et al. — Journal of biological regulators and homeostatic agents