Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among ...
Mayfield CK, Bolia IK, Feingold CL et al. — The American journal of sports medicine
A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS
CJC-1295 is a peptide-based drug that stimulates the production of growth hormone (GH) from the pituitary gland. It incorporates a functional maleimido group at the C-terminus that allows it to covalently bind plasma proteins such as serum albumin...
Timms M, Ganio K, Steel R — Drug testing and analysis
An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma
CJC-1295 is a 30 amino acid peptide-based drug that stimulates the release of growth hormone (GH) from the pituitary gland. It is unique among performance-enhancing peptides due to the presence of a reactive maleimidopropionic acid group that cova...
Timms M, Ganio K, Forbes G et al. — Drug testing and analysis
Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions
Communal online folk pharmacology fuels the drive for short cuts in attaining muscle enhancement, fat loss, and youthful skin.
Van Hout MC, Hearne E — Substance use & misuse
Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
Several peptide drugs are being manufactured illicitly, and in some cases they are being made available to the public before entering or completing clinical trials. At the request of Norwegian police and customs authorities, unknown pharmaceutical...
Henninge J, Pepaj M, Hullstein I et al. — Drug testing and analysis
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum.
Sackmann-Sala L, Ding J, Frohman LA et al. — Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
Pulsatile GH secretion is considered important for many of the hormone's physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life limits its therapeutic use. A synthetic GHRH analog (...
Ionescu M, Frohman LA — The Journal of clinical endocrinology and metabolism
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Although the majority of children with isolated growth hormone (GH) deficiency have a good growth response to GH-releasing hormone (GHRH), the use of this therapeutic agent is limited by its very short half-life. Indeed, we have shown that, in mic...
Alba M, Fintini D, Sagazio A et al. — American journal of physiology. Endocrinology and metabolism
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action.
Teichman SL, Neale A, Lawrence B et al. — The Journal of clinical endocrinology and metabolism
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
In vivo bioconjugation to the free thiol on Cys34 of serum albumin by a strategically placed reactive group on a bioactive peptide is a useful tool to extend plasma half-life. Three maleimido derivates of human GH-releasing factor (hGRF)(1-29) wer...
Jetté L, Léger R, Thibaudeau K et al. — Endocrinology