Selank: Physician Review
Physician-authored review of Selank — mechanism, evidence, regulatory status, and clinical considerations. Ferguson CM — Truthe Research (2026).
Truthe take: Read the full physician-authored review.
Ferguson CM — Truthe Research
Semax: Physician Review
Physician-authored review of Semax — mechanism, evidence, regulatory status, and clinical considerations. Ferguson CM — Truthe Research (2026).
Truthe take: Read the full physician-authored review.
Ferguson CM — Truthe Research
The physiopathology of brain-derived neurotrophic factor
Brain-derived neurotrophic factor (BDNF) is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits...
Barde YA — Physiological reviews
Astrocytes and brain-derived neurotrophic factor (BDNF)
Astrocytes are emerging in the neuroscience field as crucial modulators of brain functions, from the molecular control of synaptic plasticity to orchestrating brain-wide circuit activity for cognitive processes. The cellular pathways through which...
Albini M, Krawczun-Rygmaczewska A, Cesca F — Neuroscience research
The Effect of Exercise on Neurogenesis in the Brain
The connection between physical exercise and the brain has long been studied. The evidence showing that physical exercise plays a significant role on neurogenesis and cognitive function has primarily been based on research examining aerobic exerci...
Ben-Zeev T, Shoenfeld Y, Hoffman JR — The Israel Medical Association journal : IMAJ
Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanis...
Gao L, Zhang Y, Sterling K et al. — Translational neurodegeneration
Neuroprotective Effect of SGLT2 Inhibitors
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin, Sotagliflozin) are newer hypoglycemic agents with many pleiotropic effects...
Pawlos A, Broncel M, Woźniak E et al. — Molecules (Basel, Switzerland)
The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways unde...
Amidfar M, de Oliveira J, Kucharska E et al. — Life sciences
Brain-Derived Neurotrophic Factor and Diabetes
Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disor...
Rozanska O, Uruska A, Zozulinska-Ziolkiewicz D — International journal of molecular sciences
Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions
Engagement in regular bouts of exercise confers numerous positive effects on brain health across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long-term exercise training stimulates brain plasticity, improves ...
Walsh JJ, Tschakovsky ME — Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
BDNF and synaptic plasticity, cognitive function, and dysfunction
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high level of expression in the brain and its potent effects on synapses. It is now widely accepted that the main function of BDNF in the adult brain is to regula...
Lu B, Nagappan G, Lu Y — Handbook of experimental pharmacology
Exercise: a behavioral intervention to enhance brain health and plasticity
Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly in later life. Recent studies using animal models have been directed towards understanding the neurobiological bases of...
Cotman CW, Berchtold NC — Trends in neurosciences