Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model
Inflammation serves as a basic defense mechanism against both internal and external threats, while the unresolved or excessive inflammation can lead to irreversible tissue damage. Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu), a bioactive tripeptide co...
Hu J, Zhang C, Wang F — European journal of pharmacology
Collagen Peptide Supplementation Enhances Muscle-Tendon Stiffness and Explosive Strength: A 16-wk Randomized Controlled Trial
This study investigated whether 16 wk of daily collagen peptide (CP) supplementation affect muscle and tendon stiffness and explosive muscle strength.
Miyamoto N, Ishihara K, Oshima T et al. — Medicine and science in sports and exercise
Copper Complexes with New Glycyl-l-histidyl-l-lysine-Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects
In recent years, hyaluronic acid (HA) and the natural tripeptide glycyl-l-histidyl-l-lysine (GHK), especially its copper(II) complex (GHK-Cu), individually have been shown to exert helpful properties for bone protection and regeneration. However, ...
Greco V, Lanza V, Tomasello B et al. — Bioconjugate chemistry
An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant
With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidan...
Hu D, Zhang X, Gong S et al. — Colloids and surfaces. B, Biointerfaces
Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its thera...
Mao S, Huang J, Li J et al. — Frontiers in pharmacology
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application. This simple sequence of amino acid residues not only has...
Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR — BioImpacts : BI
Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in the human bod...
Ogórek K, Nowak K, Wadych E et al. — Molecules (Basel, Switzerland)
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study
Menisci, one of the most important anatomical structures of the knee joint, plays a role in load transfer, stability, shock absorption, prevention of articular cartilage degeneration, and proprioception. Type I collagen, the main component of the ...
Genç AS, Yılmaz AK, Anıl B et al. — BMC musculoskeletal disorders
Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial
Knee osteoarthritis (OA) is a common degenerative joint disease with limited safe, long-term treatment options. Nutritional interventions, such as low-molecular-weight collagen peptides (LMCP), have emerged as promising non-pharmacological strateg...
Park SY, Lee SH, Kim HT et al. — Frontiers in nutrition
The glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6
Silicosis is the most common type of pneumoconiosis, having a high incidence in workers chronically exposed to crystalline silica (CS). No specific medication exists for this condition. GHK, a tripeptide naturally occurring in human blood and urin...
Bian Y, Deng M, Liu J et al. — Redox biology
The potential of GHK as an anti-aging peptide
GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. The molecule has a very high affinity for copper and forms the chel...
Dou Y, Lee A, Zhu L et al. — Aging pathobiology and therapeutics
Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis
Over the past decade, collagen peptide (CP) supplements have received considerable attention in sports nutrition research. These supplements have shown promising results in improving personal health, enhancing athletic performance, and preventing ...
Bischof K, Moitzi AM, Stafilidis S et al. — Sports medicine (Auckland, N.Z.)
Collagen Peptide Supplementation during Training Does Not Further Increase Connective Tissue Protein Synthesis Rates
Protein supplementation increases postexercise muscle protein synthesis rates and, as such, supports exercise-induced muscle conditioning. Collagen protein has been suggested as the preferred protein source to stimulate muscle connective protein s...
Kirmse M, Lottmann TM, Volk NR et al. — Medicine and science in sports and exercise
Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing
Satisfactory healing following acute tendon injury is marred by fibrosis. Despite the high frequency of tendon injuries and poor outcomes, there are no pharmacological therapies in use to enhance the healing process. Moreover, systemic treatments ...
Adjei-Sowah E, Chandrasiri I, Xiao B et al. — Science advances
Dendritic Cell-Derived Exosomes Promote Tendon Healing and Regulate Macrophage Polarization in Preventing Tendinopathy
Tendon injuries present a significant challenge for independent repair, and can progress into tendinopathy over time, highlighting the importance of early intervention. Dendritic cell-derived exosomes (DEXs) has been shown to shift the polarizatio...
Chen R, Ai L, Zhang J et al. — International journal of nanomedicine
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair
Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain signals; however, the role of peripheral nerves in tendon injury and repair remains unclear. Here, we show that after Achilles tendon injury in mice, there is ...
Cherief M, Xu J, Li Z et al. — Science translational medicine
Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway
Skeletal muscle dysfunction is an important co-morbidity in patients with chronic obstructive pulmonary disease (COPD) and is significantly associated with increased mortality. Oxidative stress has been demonstrated an important trigger for COPD-r...
Deng M, Zhang Q, Yan L et al. — Journal of cachexia, sarcopenia and muscle
Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults
Chronic pain affects 19% of adults in the United States, with increasing prevalence in active and aging populations. Pain can limit physical activity and activities of daily living (ADLs), resulting in declined mental and social health. Nutritiona...
Kviatkovsky SA, Hickner RC, Cabre HE et al. — Journal of the International Society of Sports Nutrition
The mechanisms and functions of TGF-β1 in tendon healing
Tendon injury accounts for 30% of musculoskeletal diseases and often leads to disability, pain, healthcare cost, and lost productivity. Following injury to tendon, tendon healing proceeds via three overlapping healing processes. However, due to th...
Li H, Luo S, Wang H et al. — Injury
Current Advancements and Strategies of Biomaterials for Tendon Repair: A Review
Tendon is a bundle of tissue comprising of a large number of collagen fibers that connects muscle to bone. However, overuse or trauma may cause degeneration and rupture of the tendon tissues, which imposes an enormous health burden on patients. In...
Yu X, Cui J, Shen Y et al. — Frontiers in bioscience (Landmark edition)
Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment
In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications....
Elango J, Zamora-Ledezma C, Ge B et al. — Bioengineering (Basel, Switzerland)
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Collagen peptide supplementation (COL), in conjunction with exercise, may be beneficial for the management of degenerative bone and joint disorders. This is likely due to stimulatory effects of COL and exercise on the extracellular matrix of conne...
Khatri M, Naughton RJ, Clifford T et al. — Amino acids
Collagen peptide supplementation for pain and function: is it effective?
Connective tissue injuries are prevalent in active and aging populations, leading to chronic pain and decreased function. Turnover of this tissue is not well understood, especially as it relates to aging and injury. Supplementation of collagen pep...
Kviatkovsky SA, Hickner RC, Ormsbee MJ — Current opinion in clinical nutrition and metabolic care
A Promising Candidate in Tendon Healing Events-PDGF-BB
Tendon injuries are one of the most common musculoskeletal disorders for which patients seek medical aid, reducing not only the quality of life of the patient but also imposing a significant economic burden on society. The administration of growth...
Chen Y, Jiang L, Lyu K et al. — Biomolecules
Bioactive extracellular matrix fragments in tendon repair
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and ...
Mohindra R, Mohindra R, Agrawal DK et al. — Cell and tissue research
Basic Research on Tendon Repair: Strategies, Evaluation, and Development
Tendon is a fibro-elastic structure that links muscle and bone. Tendon injury can be divided into two types, chronic and acute. Each type of injury or degeneration can cause substantial pain and the loss of tendon function. The natural healing pro...
Li ZJ, Yang QQ, Zhou YL — Frontiers in medicine
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and gl...
Pickart L, Margolina A — International journal of molecular sciences
Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth
Glycine, proline, and hydroxyproline (Hyp) contribute to 57% of total amino acids (AAs) in collagen, which accounts for one-third of proteins in animals. As the most abundant protein in the body, collagen is essential to maintain the normal struct...
Li P, Wu G — Amino acids
Does Diabetes Mellitus Affect Tendon Healing?
Diabetes mellitus (DM) is a metabolic disorder resulting from defective insulin production and characterized by chronic hyperglycemia. DM affects around 170 million people worldwide and its incidence is increasing globally. DM can cause a wid...
Ahmed AS — Advances in experimental medicine and biology
Deep Venous Thrombosis and Tendon Healing
Tendon metabolism after acute Achilles tendon rupture (ATR) is associated with major complications related to immobilization, which results in reduced circulation, high risk of deep venous thrombosis (DVT), impaired healing and functional deficits...
Domeij-Arverud E, Ackermann PW — Advances in experimental medicine and biology