Aging and Thymosin Alpha-1
Aging is characterized by immune decline, mainly due to thymic involution-the age-related shrinkage of the thymus gland. This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin ...
Simonova MA, Ivanov I, Shoshina NS et al. — International journal of molecular sciences
TMSB10 drives prostate cancer aggressiveness via immune microenvironment regulation
Thymosin β10 (TMSB10) has emerged as a key player in the progression of prostate cancer, significantly influencing the tumor immune microenvironment. Pan-cancer analysis from The Cancer Genome Atlas (TCGA) revealed that TMSB10 is upregulated...
Xia H, Ning J, Guo X et al. — Molecular medicine (Cambridge, Mass.)
Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical Trials
This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials. The focus was on Tα1's application in...
Dinetz E, Lee E — Alternative therapies in health and medicine
Phenotypic drug discovery: a case for thymosin alpha-1
Phenotypic drug discovery (PDD) involves screening compounds for their effects on cells, tissues, or whole organisms without necessarily understanding the underlying molecular targets. PDD differs from target-based strategies as it does not requir...
Garaci E, Paci M, Matteucci C et al. — Frontiers in medicine
Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies
Representing severe morbidity and mortality globally, respiratory infections associated with chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung disease, and chronic obstructive pulmonary disease, are a major p...
Di YP, Kuhn JM, Mangoni ML — Physiological reviews
Therapeutic applications of thymosin peptides: a patent landscape 2018-present
Thymosins are small proteins found mainly in the thymus. They are involved in several biological processes, including immunoregulation, angiogenesis, and anti-inflammatory activity. Due to these multiple activities, thymosins are widely used as th...
Quagliata M, Papini AM, Rovero P — Expert opinion on therapeutic patents
Antimicrobial Peptide- and Dentin Matrix-Functionalized Hydrogel for Vital Pulp Therapy via Synergistic Bacteriostasis, Immunomodulation, and Dentinogenesis
The preservation of vital pulps is crucial for maintaining the physiological functions of teeth; however, vital pulp therapy (VPT) of pulpitis teeth remains a substantial challenge due to uncontrolled infection, excessive inflammation, and limited...
Xie Z, Jiang W, Liu H et al. — Advanced healthcare materials
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression
Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have immunomodulatory properties which may be beneficial in case of viral infection. This study's goal is to determine whether thymosin alpha-1 i...
Soeroto AY, Suryadinata H, Yanto TA et al. — Inflammopharmacology
Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application
Thymosin α1 (Tα1) is an immunostimulatory peptide that is commonly used as an immune enhancer in viral infectious diseases such as hepatitis B, hepatitis C, and acquired immune deficiency syndrome (AIDS). Tα1 can influence the fu...
Tao N, Xu X, Ying Y et al. — Molecules (Basel, Switzerland)
Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study
Thymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed to explore the efficacy of Tα1 as a COVID-19 therapy.
Liu J, Shen Y, Wen Z et al. — Frontiers in immunology
COVID-19: Imbalanced Immune Responses and Potential Immunotherapies
The ongoing pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading and has resulted in grievous morbidity and mortality worldwide. Despite the high infectiousness of...
Xie B, Zhang J, Li Y et al. — Frontiers in immunology
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymos...
Armirotti A, Tomati V, Matthes E et al. — Scientific reports
Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes
Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral...
Chessa C, Bodet C, Jousselin C et al. — Frontiers in microbiology
Serum thymosin alpha 1 levels in normal and pathological conditions
Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the organism homeostasis. It has been chemically synthesized and used in diseases where the immune system is hindered or malfunctioning.
Pica F, Gaziano R, Casalinuovo IA et al. — Expert opinion on biological therapy
Immune Modulation with Thymosin Alpha 1 Treatment
Thymosin alpha 1 (Ta1) is a peptide originally isolated from thymic tissue as the compound responsible for restoring immune function to thymectomized mice. Ta1 has a pleiotropic mechanism of action, affecting multiple immune cell subsets that are ...
King R, Tuthill C — Vitamins and hormones
Thymosin alpha 1 and HIV-1: recent advances and future perspectives
In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsi...
Matteucci C, Grelli S, Balestrieri E et al. — Future microbiology
Historical review of thymosin α 1 in infectious diseases
Thymosin α 1 (Tα1) is a peptidic biological response modifier, which plays a significant role in activating and regulating various cells of the immune system. For the above-mentioned activities it is expected to exert a clinical benefi...
Camerini R, Garaci E — Expert opinion on biological therapy
Jack of all trades: thymosin α1 and its pleiotropy
Thymosin α1 (Tα1), a thymosin-related 28-mer synthetic amino-terminal acetylated peptide, has gained increasing interest in recent years, due to its pleiotropy. The peptide has been used worldwide as an adjuvant or immunotherapeutic ag...
Romani L, Moretti S, Fallarino F et al. — Annals of the New York Academy of Sciences
beta-Thymosins
The development of thymosin beta(4) from a thymic hormone to an actin-sequestering peptide and back to a cytokine supporting wound healing will be outlined. Thymosin fraction 5 consists of a mixture of polypeptides and improves immune response. St...
Hannappel E — Annals of the New York Academy of Sciences
Thymosin alpha-1
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. TA1 is a synthetic polypeptide. The drug is in Phase III trials for the treatment of hepatitis C and in P...
Ancell CD, Phipps J, Young L — American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists