Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations-A Narrative Review
Creatine monohydrate supplementation is widely used by athletes in high-intensity, power-based sports due to its ability to enhance short-term performance by increasing intramuscular phosphocreatine (PCr) stores, which aid in ATP resynthesis durin...
Gutiérrez-Hellín J, Del Coso J, Franco-Andrés A et al. — Nutrients
Creatine supplementation and endurance performance: surges and sprints to win the race
Creatine supplementation is an effective ergogenic aid to augment resistance training and improve intense, short duration, intermittent performance. The effects on endurance performance are less known. The purpose of this brief narrative review is...
Forbes SC, Candow DG, Neto JHF et al. — Journal of the International Society of Sports Nutrition
Effects of Creatine Supplementation on Brain Function and Health
While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplement...
Forbes SC, Cordingley DM, Cornish SM et al. — Nutrients
Effect of β-hydroxy-β-methylbutyrate (HMB) on the Muscle Strength in the Elderly Population: A Meta-Analysis
This meta-analysis aims to evaluate the effect of the emerging nutritional ingredient β-hydroxy-β-methylbutyrate (HMB) on the muscle strength of elderly people.
Lin Z, Zhao A, He J — Frontiers in nutrition
Advances in muscle health and nutrition: A toolkit for healthcare professionals
Low muscle mass and malnutrition are prevalent conditions among adults of all ages, with any body weight or body mass index, and with acute or chronic conditions, including COVID-19. This article synthesizes the latest research advancements in mus...
Prado CM, Landi F, Chew STH et al. — Clinical nutrition (Edinburgh, Scotland)
Effects of β-hydroxy β-methylbutyrate (HMB) supplementation on muscle mass, function, and other outcomes in patients with cancer: a systematic review
Low muscle mass is prevalent among patients with cancer and a predictor of adverse clinical outcomes. To counteract muscle loss, β-hydroxy β-methylbutyrate (HMB) supplementation has been proposed as a potential therapy for older adults...
Prado CM, Orsso CE, Pereira SL et al. — Journal of cachexia, sarcopenia and muscle
Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that creatine supplementation produces a variety of beneficial effects...
Antonio J, Candow DG, Forbes SC et al. — Journal of the International Society of Sports Nutrition
Creatine Supplementation: An Update
Creatine is a popular and widely used ergogenic dietary supplement among athletes, for which studies have consistently shown increased lean muscle mass and exercise capacity when used with short-duration, high-intensity exercise. In addition to st...
Hall M, Manetta E, Tupper K — Current sports medicine reports
Creatine in Health and Disease
Although creatine has been mostly studied as an ergogenic aid for exercise, training, and sport, several health and potential therapeutic benefits have been reported. This is because creatine plays a critical role in cellular metabolism, particula...
Kreider RB, Stout JR — Nutrients
Timing of Creatine Supplementation around Exercise: A Real Concern?
Creatine has been considered an effective ergogenic aid for several decades; it can help athletes engaged in a variety of sports and obtain performance gains. Creatine supplementation increases muscle creatine stores; several factors have been ide...
Ribeiro F, Longobardi I, Perim P et al. — Nutrients
Creatine Supplementation and Brain Health
There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be ben...
Roschel H, Gualano B, Ostojic SM et al. — Nutrients
Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
Creatine is one of the most studied and popular ergogenic aids for athletes and recreational weightlifters seeking to improve sport and exercise performance, augment exercise training adaptations, and mitigate recovery time. Studies consistently r...
Wax B, Kerksick CM, Jagim AR et al. — Nutrients
Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses
Sarcopenia is a progressive and generalized skeletal muscle disorder associated with an increased risk of adverse outcomes such as falls, disability, and death. The Belgian Society of Gerontology and Geriatrics has developed evidence-based guideli...
Gielen E, Beckwée D, Delaere A et al. — Nutrition reviews
Nutrition interventions to treat low muscle mass in cancer
Many patients with cancer experience poor nutritional status, which detrimentally impacts clinical outcomes. Poor nutritional status in cancer is primarily manifested by severe muscle mass (MM) depletion, which may occur at any stage (from curativ...
Prado CM, Purcell SA, Laviano A — Journal of cachexia, sarcopenia and muscle
Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions
Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite of the essential amino acid leucine that has been reported to have anabolic effects on protein metabolism. The aims of this article were to summarize the results of studies of the effects of H...
Holeček M — Journal of cachexia, sarcopenia and muscle
The role of leucine and its metabolites in protein and energy metabolism
Leucine (Leu) is a nutritionally essential branched-chain amino acid (BCAA) in animal nutrition. It is usually one of the most abundant amino acids in high-quality protein foods. Leu increases protein synthesis through activation of the mammalian ...
Duan Y, Li F, Li Y et al. — Amino acids
Glucocorticoid-induced skeletal muscle atrophy
Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger...
Schakman O, Kalista S, Barbé C et al. — The international journal of biochemistry & cell biology
Creatine and creatinine metabolism
The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of ...
Wyss M, Kaddurah-Daouk R — Physiological reviews