Regulation of LL-37 in Bone and Periodontium Regeneration
The goal of regenerative therapy is to restore the structure and function of the lost tissues in the fields of medicine and dentistry. However, there are some challenges in regeneration therapy such as the delivery of oxygen and nutrition, and the...
Chinipardaz Z, Zhong JM, Yang S — Life (Basel, Switzerland)
Cathelicidin LL-37 in Health and Diseases of the Oral Cavity
The mechanisms for maintaining oral cavity homeostasis are subject to the constant influence of many environmental factors, including various chemicals and microorganisms. Most of them act directly on the oral mucosa, which is the mechanical and i...
Tokajuk J, Deptuła P, Piktel E et al. — Biomedicines
The LL-37 domain: A clue to cathelicidin immunomodulatory response?
Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate immunomodulatory responses. Cathelicidins, a family of HDPs, are prod...
Leite ML, Duque HM, Rodrigues GR et al. — Peptides
LL-37 Triggers Antimicrobial Activity in Human Platelets
Platelets play a crucial role in hemostasis and the immune response, mainly by recognizing signals associated with vascular damage. However, it has recently been discovered that the antimicrobial peptide LL-37 activates platelets in functions rela...
Sánchez-Peña FJ, Romero-Tlalolini MLÁ, Torres-Aguilar H et al. — International journal of molecular sciences
Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions
Exosomes show great potential in diagnostic and therapeutic applications. Inspired by the human innate immune defense, herein, we report engineered exosomes derived from monocytic cells treated with immunomodulating compounds 1α,25-dihydroxy...
Su Y, Sharma NS, John JV et al. — Advanced healthcare materials
The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from antibiotic r...
Ridyard KE, Overhage J — Antibiotics (Basel, Switzerland)
Psoriasis and Antimicrobial Peptides
Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) such as β-defensin, S100, and cathelicidin are secreted fr...
Takahashi T, Yamasaki K — International journal of molecular sciences
The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
Development of novel antimicrobial agents is a top priority in the fight against multidrug-resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial and antibiofilm peptides (SAAPs) with enhanced antimicrobial activi...
de Breij A, Riool M, Cordfunke RA et al. — Science translational medicine
Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer
LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesi...
Chen X, Zou X, Qi G et al. — Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cathelicidin LL-37: a multitask antimicrobial peptide
The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 pepti...
Bucki R, Leszczyńska K, Namiot A et al. — Archivum immunologiae et therapiae experimentalis