Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food
Obesity is a major health problem worldwide. An understanding of the factors that drive feeding behaviors is key to the development of pharmaceuticals to decrease appetite and consumption. Proopiomelanocortin (POMC), the melanocortin peptide precu...
Eliason NL, Martin L, Low MJ et al. — Neuropeptides
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
The pleiotropic role played by melanocortin receptors (MCRs) in both physiological and pathological processes has stimulated medicinal chemists to develop synthetic agonists/antagonists with improved potency and selectivity. Here, by deploying the...
Tomassi S, Dimmito MP, Cai M et al. — Journal of medicinal chemistry
A glimpse into the underground market of melanotan
Melanotan-I and melanotan-II are alpha-melanocyte stimulating hormone (a-MSH) analogues that can be purchased illicitly online with relative ease and are injected subcutaneously to stimulate a tan. Little is known about the use of these unregulate...
Callaghan Iii DJ — Dermatology online journal
Melanoma associated with the use of melanotan-II
Unlicensed use of melanotan-II (MT-II) to promote skin pigmentation has become prevalent amongst young people attending fitness centres. We present a case where the melanocyte stimulation of MT-II in combination with the use of sun tanning beds co...
Hjuler KF, Lorentzen HF — Dermatology (Basel, Switzerland)
The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats
The aim of this study is to demonstrate that monitoring, by means of telemetry technology, the increases in intracavernosal pressure (ICP) in freely moving rats using melanotan-II (MT-II) as a proerectile inducer compound is a relevant experimenta...
Giuliano F, Rössler AS, Clément P et al. — European urology
The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat
The neurotrophic and neuroprotective potential of the alpha-melanocyte-stimulating hormone (alpha-MSH) analog cyclo-[Ac-Nle(4),Asp(5),D-Phe(7),Lys(10)]alpha-MSH-(4-10) amide (melanotan-II), a potent melanocortin receptor agonist, was investigated....
Ter Laak MP, Brakkee JH, Adan RA et al. — European journal of pharmacology
Co-treatment with melanotan-II, a potent melanocortin, does not protect against cisplatin ototoxicity
Cisplatin, an important chemotherapeutic agent, has severe dose-limiting side effects including peripheral neurotoxicity and ototoxicity. Peripheral neurotoxicity can be delayed or prevented by simultaneous treatment with a class of neuropeptides ...
Wolters FL, de Vocht TF, Klis SF et al. — Hearing research
Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study
A pilot phase I study was conducted with a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). The lactam-bridged molecule, called Melanotan-II (MT-II), has the structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-M...
Dorr RT, Lines R, Levine N et al. — Life sciences