Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies
Neuromuscular disorders are a heterogeneous group of acquired or hereditary conditions that affect striated muscle function. The resulting decrease in muscle strength and motility irreversibly impacts quality of life. In addition to directly affec...
Ganassi M, Zammit PS — European journal of translational myology
The satellite cell in skeletal muscle: A story of heterogeneity
Skeletal muscle is a highly represented tissue in mammals and is composed of fibers that are extremely adaptable and capable of regeneration. This characteristic of muscle fibers is made possible by a cell type called satellite cells. Adjacent to ...
Guilhot C, Catenacci M, Lofaro S et al. — Current topics in developmental biology
Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis
Satellite cells are skeletal muscle stem cells that contribute to postnatal muscle growth, and they endow skeletal muscle with the ability to regenerate after a severe injury. Here we discover that this myogenic potential of satellite cells requir...
Lin KH, Hibbert JE, Flynn CG et al. — EMBO reports
Satellite cell dynamics during skeletal muscle hypertrophy
Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmet...
Saliu TP, Goh J, Kang G et al. — Biochemical Society transactions
SRSF1 Is Crucial for Maintaining Satellite Cell Homeostasis During Skeletal Muscle Growth and Regeneration
The splicing factor SRSF1 emerges as a mater regulator of cell proliferation, displaying high expression in actively proliferative satellite cells (SCs). In SRSF1 knockout mice (KO) generated via MyoD-Cre, early mortality and muscle atrophy are ob...
Wang Z, Peng Q, Zhang Z et al. — Journal of cachexia, sarcopenia and muscle
Circadian timing of satellite cell function and muscle regeneration
Recent research has highlighted an important role for the molecular circadian machinery in the regulation of tissue-specific function and stress responses. Indeed, disruption of circadian function, which is pervasive in modern society, is linked t...
Zhu P, Peek CB — Current topics in developmental biology
Lactate Metabolism and Satellite Cell Fate
Lactate is one of the metabolic products of glycolysis. It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. Satellite cells (SCs), which ar...
Nalbandian M, Radak Z, Takeda M — Frontiers in physiology
Control of satellite cell function in muscle regeneration and its disruption in ageing
Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres...
Sousa-Victor P, García-Prat L, Muñoz-Cánoves P — Nature reviews. Molecular cell biology
Satellite Cell Self-Renewal
Adult skeletal muscle is endowed with regenerative potential through partially recapitulating the embryonic developmental program. Upon acute injury or in pathological conditions, quiescent muscle-resident stem cells, called satellite cells, becom...
Giordani L, Parisi A, Le Grand F — Current topics in developmental biology
Muscle satellite cell heterogeneity and self-renewal
Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of...
Motohashi N, Asakura A — Frontiers in cell and developmental biology