Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has be...
Filippenkov IB, Stavchansky VV, Denisova AE et al. — Genes
[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]
To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS).
Gusev EI, Martynov MY, Kostenko EV et al. — Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax
The effect of peptide Semax on remodeling of cardiac sympathetic innervation was examined in rats with experimental myocardial infarction. In 28 days after ischemia/reperfusion injury, Semax diminished the growth of sympathetic innervation of vent...
Gavrilova SA, Markov MA, Berdalin AB et al. — Bulletin of experimental biology and medicine
Effects of Semax on the Default Mode Network of the Brain
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 wom...
Lebedeva IS, Panikratova YR, Sokolov OY et al. — Bulletin of experimental biology and medicine
Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone and a C-terminal Pro-Gly-Pro tripeptide. N-terminal amino group acetylation (Ac-Semax) modulates the ch...
Magrì A, Tabbì G, Giuffrida A et al. — Journal of inorganic biochemistry
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, the molecular mechanisms underlying its action remain obscure. Our genome-wide study was designed to investigat...
Medvedeva EV, Dmitrieva VG, Povarova OV et al. — BMC genomics
[Nootropic and analgesic effects of Semax following different routes of administration]
Heptapeptide Semax (MEHFPGP) is the fragment of ACTH(4-10) analogue with prolonged neurotropic activity. The aim of the present work was to study the Semax effects on learning capability and pain sensitivity in white rats following intraperitoneal...
Manchenko DM, Glazova NIu, Levitskaia NG et al. — Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
[Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application]
Experimental and theoretical demonstration of different effect of certain regulatory peptides (RPs) on blood coagulation is available. The problem of the role of RPs in hemostatic processes becomes particularly significant since, first, the peptid...
Liapina LA, Pastorova VE, Obergan TIu et al. — Izvestiia Akademii nauk. Seriia biologicheskaia