Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
Background: Body protection compound-157 (BPC-157) is a naturally occurring gastric peptide that promotes mucosal integrity and homeostasis. Preclinical studies show its potential for promoting healing in musculoskeletal injuries such as fractures...
Vasireddi N, Hahamyan H, Salata MJ et al. — HSS journal : the musculoskeletal journal of Hospital for Special Surgery
Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance?
High-level athletes and bodybuilders are constantly seeking novel therapies to enhance recovery and expedite return from injury-injectable peptides are a new and trending therapy that may be the wave of the future in the realm of regenerative medi...
DeFoor MT, Dekker TJ — Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review
BPC 157, known as the "Body Protection Compound", is a pentadecapeptide isolated from human gastric juice that demonstrated its pleiotropic beneficial effects in various preclinical models mimicking medical conditions, such as tissue injury, infla...
Józwiak M, Bauer M, Kamysz W et al. — Pharmaceuticals (Basel, Switzerland)
Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing
This scoping review aims to evaluate the molecular mechanisms, therapeutic potential, and safety concerns of Body Protective Compound-157 (BPC-157) in the context of musculoskeletal healing. Given the compound’s increasing availability, pop...
McGuire FP, Martinez R, Lenz A et al. — Current reviews in musculoskeletal medicine
Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study
Moderate to severe interstitial cystitis (also known as bladder pain syndrome) is a disabling disease with no effective treatment. Although pentosan polysulfate is an approved treatment for interstitial cystitis, some patients on this medication e...
Lee E, Walker C, Ayadi B — Alternative therapies in health and medicine
The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity
We highlight the particular aspects of the stable gastric pentadecapeptide BPC 157 pleiotropic beneficial activity (not destroyed in human gastric juice, native and stable in human gastric juice, as a cytoprotection mediator holds a response speci...
Sikiric P, Boban Blagaic A, Strbe S et al. — Pharmaceuticals (Basel, Switzerland)
Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing
Satisfactory healing following acute tendon injury is marred by fibrosis. Despite the high frequency of tendon injuries and poor outcomes, there are no pharmacological therapies in use to enhance the healing process. Moreover, systemic treatments ...
Adjei-Sowah E, Chandrasiri I, Xiao B et al. — Science advances
Dendritic Cell-Derived Exosomes Promote Tendon Healing and Regulate Macrophage Polarization in Preventing Tendinopathy
Tendon injuries present a significant challenge for independent repair, and can progress into tendinopathy over time, highlighting the importance of early intervention. Dendritic cell-derived exosomes (DEXs) has been shown to shift the polarizatio...
Chen R, Ai L, Zhang J et al. — International journal of nanomedicine
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair
Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain signals; however, the role of peripheral nerves in tendon injury and repair remains unclear. Here, we show that after Achilles tendon injury in mice, there is ...
Cherief M, Xu J, Li Z et al. — Science translational medicine
The mechanisms and functions of TGF-β1 in tendon healing
Tendon injury accounts for 30% of musculoskeletal diseases and often leads to disability, pain, healthcare cost, and lost productivity. Following injury to tendon, tendon healing proceeds via three overlapping healing processes. However, due to th...
Li H, Luo S, Wang H et al. — Injury
Current Advancements and Strategies of Biomaterials for Tendon Repair: A Review
Tendon is a bundle of tissue comprising of a large number of collagen fibers that connects muscle to bone. However, overuse or trauma may cause degeneration and rupture of the tendon tissues, which imposes an enormous health burden on patients. In...
Yu X, Cui J, Shen Y et al. — Frontiers in bioscience (Landmark edition)
Cytoprotective gastric pentadecapeptide BPC 157 resolves major vessel occlusion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome
The stable gastric pentadecapeptide BPC 157 counteracts various venous occlusion-induced syndromes. Summarized are all these arguments, in the Robert's cytoprotection concept, to substantiate the resolution of different major vessel occlusion dist...
Sikiric P, Skrtic A, Gojkovic S et al. — World journal of gastroenterology
Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
First, we review the definitively severed myotendinous junction and recovery by the cytoprotective stable gastric pentadecapeptide BPC 157 therapy, its healing that might combine both transected and detached tendon and transected muscle, ligament ...
Staresinic M, Japjec M, Vranes H et al. — Biomedicines
A Promising Candidate in Tendon Healing Events-PDGF-BB
Tendon injuries are one of the most common musculoskeletal disorders for which patients seek medical aid, reducing not only the quality of life of the patient but also imposing a significant economic burden on society. The administration of growth...
Chen Y, Jiang L, Lyu K et al. — Biomolecules
Bioactive extracellular matrix fragments in tendon repair
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and ...
Mohindra R, Mohindra R, Agrawal DK et al. — Cell and tissue research
Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain
Knee pain, a common complaint in primary care, has many causes, the most common of which is osteoarthritis (OA). Other common causes are meniscus tears, tendinosis, ligament tears or sprains, rheumatoid arthritis, lupus and septic arthritis. Also,...
Lee E, Padgett B — Alternative therapies in health and medicine
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound the...
Seiwerth S, Milavic M, Vukojevic J et al. — Frontiers in pharmacology
Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy
This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, con...
Sikiric P, Drmic D, Sever M et al. — Current pharmaceutical design
Pentadecapeptide BPC 157 and the central nervous system
We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and therapy application in the central nervous sys...
Vukojevic J, Milavić M, Perović D et al. — Neural regeneration research
Basic Research on Tendon Repair: Strategies, Evaluation, and Development
Tendon is a fibro-elastic structure that links muscle and bone. Tendon injury can be divided into two types, chronic and acute. Each type of injury or degeneration can cause substantial pain and the loss of tendon function. The natural healing pro...
Li ZJ, Yang QQ, Zhou YL — Frontiers in medicine
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
There is a current need for a therapy that can alleviate the social and economic burden that presents itself with debilitating and recurring musculoskeletal soft tissue injuries and disorders. Currently, several therapies are emerging and undergoi...
Gwyer D, Wragg NM, Wilson SL — Cell and tissue research
BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing
Commonly, the angiogenic growth factors signify healing. However, gastrointestinal ulceration is still poorly understood particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemente...
Seiwerth S, Rucman R, Turkovic B et al. — Current pharmaceutical design
Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME
To counteract/reveal celecoxib-induced toxicity and NO system involvement.
Drmic D, Kolenc D, Ilic S et al. — World journal of gastroenterology
Does Diabetes Mellitus Affect Tendon Healing?
Diabetes mellitus (DM) is a metabolic disorder resulting from defective insulin production and characterized by chronic hyperglycemia. DM affects around 170 million people worldwide and its incidence is increasing globally. DM can cause a wid...
Ahmed AS — Advances in experimental medicine and biology
Deep Venous Thrombosis and Tendon Healing
Tendon metabolism after acute Achilles tendon rupture (ATR) is associated with major complications related to immobilization, which results in reduced circulation, high risk of deep venous thrombosis (DVT), impaired healing and functional deficits...
Domeij-Arverud E, Ackermann PW — Advances in experimental medicine and biology
Stable gastric pentadecapeptide BPC 157-NO-system relation
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular heali...
Sikiric P, Seiwerth S, Rucman R et al. — Current pharmaceutical design
Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin
Recently, in rat abdominal aorta terminoterminal-anastomosis the stable gastric pentadecapeptide BPC 157 prevents obstructive thrombus formation and rapidly destroys already formed obstructive thrombus. Also, BPC 157 wound healing may signify the ...
Stupnisek M, Franjic S, Drmic D et al. — Thrombosis research
Long-lasting cytoprotection after pentadecapeptide BPC 157, ranitidine, sucralfate or cholestyramine application in reflux oesophagitis in rats
Recently, the effectiveness of pentadecapeptide BPC 157 and other anti-ulcer agents, called 'direct cytoprotection', was evidenced in totally gastrectomized rats duodenum challenged with cysteamine 24 h after surgery, and sacrificed 24 h after ulc...
Sikiric P, Jadrijevic S, Seiwerth S et al. — Journal of physiology, Paris