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Physician-authored overviews of mechanism, evidence, and regulatory status. Written for patients and clinicians.
Primary Research & Sources
Peer-reviewed studies from PubMed and clinical journals
FDA finalized the reclassification of seven peptides previously available through 503A compounding pharmacies. BPC-157, TB-500, KPV, DSIP, Epitalon, LL-37, Selank, Semax, and Melanotan II are no longer eligible for traditional compounding. Advisory panel for remaining peptides scheduled July 2026.
Truthe take: This is the regulatory event we have been tracking since 2024. Some compounds in our protocols are affected. We have updated our formulary and our patients have been notified. The July panel will determine the next wave.
Review of sermorelin as a GHRH analog for restoring pulsatile growth hormone secretion. Documented safety profile in adults with age-related GH decline. Does not suppress endogenous GH production, unlike exogenous GH.
Truthe take: Sermorelin is the reason we use GHRH analogs instead of injecting growth hormone directly. It restores the body's own pulsatile pattern. Safer, more physiologic, less regulatory risk.
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