MOTS-c
MOTTS-see
A peptide encoded by your mitochondrial DNA that acts as an exercise mimetic — activating the same pathways as a workout.
Also known as: Mitochondrial ORF of the Twelve S rRNA Type-c
Last reviewed: April 2026
What It Does
MOTS-c is unique — it's encoded by mitochondrial DNA, not nuclear DNA. It acts like a signal your mitochondria send to the rest of your body when they're under metabolic stress (like exercise). It activates AMPK, the same pathway triggered by exercise, promoting fat burning, insulin sensitivity, and metabolic health.
Why People Take It
How It's Administered
Subcutaneous Injection
Small injection, typically in the morning
Frequency
3–5 times per week
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
5mg – 10mg
What To Expect
Week 2–4
Improved metabolic markers. Better exercise tolerance.
Month 2+
Sustained metabolic and body composition benefits.
Side Effects
Overall: Mild
Common (1–10%)
Injection site reaction
Mild discomfort at site.
Who Should NOT Take This
• Active cancer
• Pregnancy
• Limited human data
Drug Interactions
• Diabetes medications — may enhance glucose-lowering effects
Pregnancy: Not studied in pregnancy. Avoid.
Clinical Details
Compare With Similar Peptides
MOTS-c mimics exercise (AMPK activation). Rapamycin mimics fasting (mTOR inhibition). NAD+ supports energy production. All three target different longevity pathways.
Rapamycin
The most studied longevity compound — activates cellular cleanup by telling your cells to switch from 'growth mode' to 'maintenance mode.'
NAD+
A coenzyme in every cell that powers your mitochondria — levels drop with age, and restoring them supports energy and cellular repair.
Frequently Asked Questions
We don't currently offer this peptide — but we have protocols for similar goals.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.