ser-more-ELL-in
A peptide that tells your pituitary gland to make more growth hormone naturally — supports sleep, recovery, and body composition.
Also known as: Geref, GHRH 1-29
Last reviewed: April 2026
Instead of injecting growth hormone directly, sermorelin sends a signal to your pituitary gland to produce more of its own. This preserves your body's natural feedback loops — you get the benefits of higher growth hormone without the risks of direct HGH replacement. Better sleep, faster recovery, improved body composition, and enhanced skin quality are the main outcomes.
Small needle into belly fat at bedtime (GH pulses during sleep)
Frequency
5 nights per week
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
200mcg – 500mcg nightly
Week 1–2
Improved sleep quality is often the first thing noticed.
Month 1
Better recovery, more energy, improved sleep depth.
Month 3+
Body composition changes — more lean mass, less fat. Skin improvements.
Overall: Mild
Injection site reaction
Redness or itching at injection site.
Headache
Usually temporary.
Flushing
Warm feeling shortly after injection.
• Active cancer
• Pregnant or breastfeeding
• Hypersensitivity to sermorelin
• Glucocorticoids — may blunt GH response
• Insulin — GH can affect blood sugar
Pregnancy: Not studied in pregnancy. Do not use while pregnant or breastfeeding.
Sermorelin is the simplest GHRH analog. CJC-1295 lasts longer. Ipamorelin works through a different receptor (ghrelin). Combining CJC+Ipamorelin hits both pathways.
CJC-1295
A long-acting growth hormone releaser that provides sustained GH stimulation over days rather than minutes.
Ipamorelin
A selective growth hormone releaser that works through the 'hunger hormone' pathway — clean GH stimulation with fewer side effects.
CJC-1295 / Ipamorelin
The most popular growth hormone peptide combination — hits two pathways simultaneously for amplified GH release.
Tesamorelin
An FDA-approved growth hormone releasing peptide that specifically reduces visceral (belly) fat.
Interested? A licensed provider will evaluate if this is appropriate for you.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.