CJC-1295
C-J-C twelve-ninety-five
A long-acting growth hormone releaser that provides sustained GH stimulation over days rather than minutes.
Also known as: CJC-1295 DAC, Modified GRF 1-29
Last reviewed: April 2026
What It Does
CJC-1295 is a modified version of your natural GHRH (the signal that tells your pituitary to release growth hormone). The modification makes it last days instead of minutes. This provides a sustained elevation of growth hormone — supporting muscle recovery, fat loss, sleep quality, and tissue repair.
Why People Take It
How It's Administered
Subcutaneous Injection
Injection before bed to work with natural GH pulses
Frequency
2–3 times per week (DAC) or daily (no DAC)
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
100mcg – 300mcg
What To Expect
Week 1–2
Improved sleep quality.
Month 1–2
Enhanced recovery, more energy.
Month 3+
Body composition improvements, skin quality changes.
Side Effects
Overall: Mild
Common (1–10%)
Water retention
Mild fluid retention, especially early on.
Injection site reaction
Redness or itching.
Uncommon (0.1–1%)
Tingling/numbness
In hands or feet, related to GH effects.
Who Should NOT Take This
• Active cancer
• Pituitary tumors
• Pregnancy
Drug Interactions
• Glucocorticoids — may blunt growth hormone release
• Insulin — GH can affect blood sugar
Pregnancy: Not studied in pregnancy. Avoid.
Clinical Details
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Half-Life
~8 days (with DAC) or ~30 minutes (without DAC)
Bioavailability
Subcutaneous absorption is effective
Mechanism of Action
Modified GHRH analog with Drug Affinity Complex (DAC) that binds albumin, extending half-life from minutes to ~8 days. Stimulates sustained pulsatile GH release from pituitary somatotrophs.
Published Research
CJC-1295 Sustained GH Release in Humans (2006) ↗Compare With Similar Peptides
Longer-lasting than sermorelin. Often combined with ipamorelin for dual-pathway GH stimulation.
Sermorelin
A peptide that tells your pituitary gland to make more growth hormone naturally — supports sleep, recovery, and body composition.
Ipamorelin
A selective growth hormone releaser that works through the 'hunger hormone' pathway — clean GH stimulation with fewer side effects.
CJC-1295 / Ipamorelin
The most popular growth hormone peptide combination — hits two pathways simultaneously for amplified GH release.
Frequently Asked Questions
This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.