Epitalon
eh-PIT-ah-lon
A synthetic version of a pineal gland peptide that may activate telomerase — the enzyme that maintains chromosome caps associated with aging.
Also known as: Epithalon, Epithalone, AGAG
Last reviewed: April 2026
What It Does
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on epithalamin, a pineal gland extract. In research, it has been shown to activate telomerase — the enzyme that maintains telomeres (the protective caps on your chromosomes that shorten with age). It may also regulate melatonin production and circadian rhythm.
Why People Take It
How It's Administered
Subcutaneous Injection
Injection into belly fat
Frequency
Daily for 10-20 day cycles, 2-3 times per year
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
5mg – 10mg daily
What To Expect
During cycle
Some report improved sleep from melatonin regulation.
After cycle
Potential long-term telomere maintenance (not measurable short-term).
Side Effects
Overall: Mild
Common (1–10%)
Injection site reaction
Mild discomfort.
Who Should NOT Take This
• Active cancer (telomerase activation)
• Pregnancy
Drug Interactions
• Limited data available
Pregnancy: Not studied. Avoid during pregnancy.
Clinical Details
Compare With Similar Peptides
Different anti-aging mechanism. Rapamycin targets mTOR/autophagy. Epitalon targets telomeres. Limited head-to-head data. Rapamycin has far more research support.
Rapamycin
The most studied longevity compound — activates cellular cleanup by telling your cells to switch from 'growth mode' to 'maintenance mode.'
Humanin
A mitochondrial-encoded peptide that protects cells from stress and death — one of the most exciting longevity research molecules.
Frequently Asked Questions
This compound is in early research stages. We do not currently offer it.
Looking for something similar? See what we offer for Longevity.
This compound is in early research stages. It has not been FDA-approved and may not be available through compounding pharmacies. The information below is for educational purposes only. Do not attempt to self-administer research compounds.