Humanin
HYOO-man-in
A mitochondrial-encoded peptide that protects cells from stress and death — one of the most exciting longevity research molecules.
Also known as: HN, Humanin Peptide
Last reviewed: April 2026
What It Does
Humanin is a 24-amino-acid peptide encoded by mitochondrial DNA. It protects cells from apoptosis (programmed death), reduces inflammation, and improves insulin sensitivity. Blood levels of humanin decline with age and correlate with healthspan. It's one of the 'mitochondrial-derived peptides' (MDPs) — signals your mitochondria send to protect the cell.
Why People Take It
How It's Administered
Subcutaneous Injection
Injection
Frequency
Research dosing
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
Research dosing only
What To Expect
Ongoing research
Human dosing timelines not established.
Side Effects
Overall: Mild
Uncommon (0.1–1%)
Limited human data
Side effect profile not well characterized in humans.
Who Should NOT Take This
• Active cancer (anti-apoptotic effects)
• Pregnancy
Drug Interactions
• Insufficient data
Pregnancy: Not studied. Avoid.
Clinical Details
Compare With Similar Peptides
All three are mitochondrial-related peptides. MOTS-c mimics exercise. SS-31 stabilizes mitochondrial membranes. Humanin protects cells from death. Complementary longevity mechanisms.
MOTS-c
A peptide encoded by your mitochondrial DNA that acts as an exercise mimetic — activating the same pathways as a workout.
SS-31 (Elamipretide)
A mitochondria-targeted peptide that concentrates inside your cells' power plants to restore their function.
Frequently Asked Questions
This compound is in early research stages. We do not currently offer it.
Looking for something similar? See what we offer for Longevity.
This compound is in early research stages. It has not been FDA-approved and may not be available through compounding pharmacies. The information below is for educational purposes only. Do not attempt to self-administer research compounds.