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The primary estrogen hormone — replacement relieves menopause symptoms and protects bone, brain, and heart health.
Also known as: E2, Estrace, Vivelle-Dot, Climara
FDA approved for: Menopausal vasomotor symptoms · Vulvovaginal atrophy · Osteoporosis prevention
Last reviewed: April 2026
Estradiol is the strongest form of estrogen your ovaries produce. When levels drop during menopause, it causes hot flashes, night sweats, brain fog, vaginal dryness, and bone loss. Replacing estradiol to physiologic levels relieves these symptoms and provides long-term protection for bones, brain, and cardiovascular system.
Patch applied to lower abdomen or hip, changed once or twice weekly
Frequency
Twice weekly (most patches)
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
0.025mg – 0.1mg/day
Gel or cream applied to skin daily
Frequency
Daily
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
0.5mg – 1.5mg daily
Week 1–2
Hot flashes and night sweats begin to improve.
Month 1
Significant reduction in vasomotor symptoms. Sleep improves.
Month 3
Brain fog lifts. Mood stabilizes. Vaginal symptoms improve.
Year 1+
Bone density stabilization. Sustained symptom relief.
Overall: Mild to Moderate
Breast tenderness
Usually resolves within 2–3 months.
Spotting
Irregular bleeding can occur in first 3 months.
Headache
Usually improves as levels stabilize.
Blood clots
Transdermal route has lowest clot risk of any form.
Call your doctor if you experience this.
• Known or suspected breast cancer
• Active blood clots or clotting disorders
• Unexplained vaginal bleeding
• Active liver disease
• Known or suspected pregnancy
• CYP3A4 inducers (rifampin, carbamazepine) — may reduce effectiveness
• Thyroid medication — may need dose adjustment
Pregnancy: Do not use during pregnancy. Estradiol is not a contraceptive.
Estradiol treats core menopause symptoms. Usually combined with progesterone for women with a uterus.
Progesterone
A natural hormone that supports sleep, mood, and hormonal balance — especially important during perimenopause and menopause.
DHEA
A precursor hormone that your adrenal glands make — your body converts it into testosterone and estrogen as needed.
Testosterone
The primary male sex hormone — replacement therapy restores levels when your body isn't making enough.
This peptide is available through our protocols.
FDA-approved for at least one indication. Your provider will determine if this is appropriate for you.