Testosterone
tess-TOSS-ter-own
The primary male sex hormone — replacement therapy restores levels when your body isn't making enough.
Also known as: Testosterone Cypionate, Test C, TRT
FDA approved for: Male hypogonadism (low testosterone)
Last reviewed: April 2026
What It Does
Testosterone is the hormone responsible for muscle mass, bone density, energy, sex drive, and mood in men. When levels drop below normal — due to age, stress, or medical conditions — replacement therapy brings them back into a healthy range. This isn't about getting to supraphysiological levels. It's about restoring what your body should be producing.
Why People Take It
How It's Administered
Intramuscular Injection
Injection into the thigh or glute muscle
Frequency
Once weekly or every 2 weeks
Pain Level
●●○ Moderate
Self-Administered
Yes — at home
Typical Range
100mg – 200mg weekly
Subcutaneous Injection
Shallow injection into belly fat with a small needle
Frequency
2–3 times per week (smaller doses)
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
40mg – 80mg per injection
Topical
Cream or gel applied to skin daily
Frequency
Daily
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
50mg – 100mg daily
What To Expect
Week 1–2
Energy and mood may start improving. Too early for physical changes.
Month 1
Improved energy, better sleep, increased libido in most men.
Month 3
Noticeable body composition changes — more muscle definition, less body fat.
Month 6+
Full benefits including bone density support, sustained energy, stable mood.
Side Effects
Overall: Mild to Moderate
Common (1–10%)
Acne
Oily skin and breakouts, especially early on.
Increased red blood cells
Monitored via bloodwork. May require dose adjustment or blood donation.
Testicular shrinkage
Natural production decreases when supplementing. Gonadorelin can prevent this.
Uncommon (0.1–1%)
Mood changes
Some men report irritability if levels spike too high.
Rare (<0.1%)
Blood clots
Leg swelling, shortness of breath — seek immediate care.
Call your doctor if you experience this.
Who Should NOT Take This
• Prostate or breast cancer (current)
• Polycythemia (high red blood cell count)
• Untreated severe sleep apnea
• Uncontrolled heart failure
• Women who are pregnant
Drug Interactions
• Blood thinners (warfarin) — may increase effect
• Insulin — may need dose adjustment
• Corticosteroids — may increase fluid retention
Pregnancy: Testosterone is contraindicated in women who are or may become pregnant. It can cause birth defects.
Clinical Details
Compare With Similar Peptides
Direct replacement vs. gonadorelin which stimulates your own production. TRT is more potent but can suppress natural production and fertility.
Gonadorelin
A natural hormone analog that tells your body to produce its own testosterone — preserves fertility unlike direct TRT.
DHEA
A precursor hormone that your adrenal glands make — your body converts it into testosterone and estrogen as needed.
Frequently Asked Questions
This peptide is available through our protocols.
FDA-approved for at least one indication. Your provider will determine if this is appropriate for you.