Gonadorelin
gon-ad-oh-RELL-in
A natural hormone analog that tells your body to produce its own testosterone — preserves fertility unlike direct TRT.
Also known as: GnRH, Factrel
Last reviewed: April 2026
What It Does
Gonadorelin mimics the master signal (GnRH) that tells your pituitary gland to produce LH and FSH, which then tell your testes to make testosterone. Unlike TRT, which replaces testosterone directly and can shut down natural production, gonadorelin works upstream through your body's own hormonal cascade.
Why People Take It
How It's Administered
Subcutaneous Injection
Small injection into belly fat
Frequency
2–3 times per week
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
100mcg – 200mcg per injection
What To Expect
Week 2–4
LH and FSH levels begin rising.
Month 1–2
Testosterone levels improve. Better energy and mood.
Month 3+
Stable testosterone levels with preserved fertility.
Side Effects
Overall: Mild
Common (1–10%)
Injection site reaction
Mild redness at injection site.
Uncommon (0.1–1%)
Headache
Usually transient.
Who Should NOT Take This
• Pituitary disorders
• Hormone-dependent tumors
Drug Interactions
• GnRH agonists/antagonists — conflicting mechanisms
Pregnancy: Not for use in women during pregnancy.
Clinical Details
Compare With Similar Peptides
Gonadorelin signals the pituitary to make LH/FSH → testosterone. TRT replaces testosterone directly. Gonadorelin preserves fertility; TRT may not.
Testosterone
The primary male sex hormone — replacement therapy restores levels when your body isn't making enough.
Kisspeptin
The 'master switch' hormone that controls your entire reproductive hormone cascade — being studied for fertility and desire.
Frequently Asked Questions
Interested? A licensed provider will evaluate if this is appropriate for you.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.