FOXO4-DRI
FOX-oh-four D-R-I
A senolytic peptide that selectively destroys 'zombie' cells (senescent cells) that accumulate with age and drive inflammation.
Also known as: FOXO4-D-Retro-Inverso
Last reviewed: April 2026
What It Does
As you age, damaged cells enter 'senescence' — they stop dividing but don't die. These 'zombie cells' secrete inflammatory molecules (SASP) that damage surrounding tissue. FOXO4-DRI disrupts the interaction between FOXO4 and p53 in senescent cells, triggering them to undergo apoptosis (self-destruct) while leaving healthy cells unharmed.
Why People Take It
How It's Administered
Subcutaneous Injection
Injection — typically in cycles
Frequency
Research dosing (often 3 consecutive days per cycle)
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
Research dosing only
What To Expect
After cycle
Senescent cell clearance occurs over days to weeks.
Weeks later
Reduced SASP markers. Potential tissue rejuvenation.
Side Effects
Overall: Mild
Uncommon (0.1–1%)
Unknown in humans
Not characterized in human studies.
Who Should NOT Take This
• Pregnancy
• Very limited human data
• Active wound healing (senescence plays a role)
Drug Interactions
• Insufficient data
Pregnancy: Not studied. Avoid.
Clinical Details
Compare With Similar Peptides
Different anti-aging strategy. Rapamycin prevents senescence (autophagy). FOXO4-DRI clears existing senescent cells. Potentially complementary.
Open Full Comparison Tool →Frequently Asked Questions
This compound is in early research stages. We do not currently offer it.
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This compound is in early research stages. It has not been FDA-approved and may not be available through compounding pharmacies. The information below is for educational purposes only. Do not attempt to self-administer research compounds.