Pregnenolone
preg-NEN-oh-lone
The very first hormone in the cascade — your body makes all other steroid hormones from this one starting material.
Also known as: The Grandmother Hormone
Last reviewed: April 2026
What It Does
Pregnenolone is made directly from cholesterol and sits at the very top of the steroid hormone tree. Your body converts it into progesterone, DHEA, cortisol, testosterone, and estrogen. It also acts directly as a neurosteroid, enhancing memory and cognitive function. Levels decline with age.
Why People Take It
How It's Administered
Oral
Capsule taken in the morning
Frequency
Daily
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
10mg – 100mg
What To Expect
Week 1–2
Some notice improved mental clarity quickly.
Month 1
Cognitive benefits and mood stabilization.
Month 3+
Sustained hormonal support and cognitive improvements.
Side Effects
Overall: Mild
Uncommon (0.1–1%)
Drowsiness
Some find it calming — can take at bedtime.
Headache
Usually with higher doses.
Who Should NOT Take This
• Hormone-sensitive cancers
• Seizure disorders (may lower threshold at high doses)
Drug Interactions
• Hormone therapies — may alter balance
• Benzodiazepines — may enhance sedation
Pregnancy: Limited safety data. Avoid during pregnancy.
Clinical Details
Compare With Similar Peptides
Pregnenolone is the starting point; DHEA and progesterone are its direct products. Pregnenolone offers the broadest hormonal support.
DHEA
A precursor hormone that your adrenal glands make — your body converts it into testosterone and estrogen as needed.
Progesterone
A natural hormone that supports sleep, mood, and hormonal balance — especially important during perimenopause and menopause.
Frequently Asked Questions
We don't currently offer this peptide — but we have protocols for similar goals.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.