Semax
SEE-max
A synthetic brain peptide derived from ACTH that enhances focus, memory, and neuroprotection — developed in Russia.
Last reviewed: April 2026
What It Does
Semax is a synthetic fragment of ACTH (adrenocorticotropic hormone) with modifications for brain specificity. It enhances BDNF production, improves attention and memory, and provides neuroprotection — without the cortisol-raising effects of natural ACTH.
Why People Take It
How It's Administered
Nasal
Nasal spray
Frequency
2–3 times daily
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
200mcg – 600mcg per dose
What To Expect
Minutes
Improved focus and mental clarity within 15–30 min.
Week 1–2
Sustained cognitive enhancement.
Month 1+
Neuroprotective benefits accumulate.
Side Effects
Overall: Mild
Common (1–10%)
Nasal irritation
From nasal spray delivery.
Uncommon (0.1–1%)
Overstimulation
Some feel jittery if prone to anxiety.
Who Should NOT Take This
• Pregnancy
• Anxiety disorders (may be stimulating for some)
Drug Interactions
• Stimulants — additive stimulating effect
Pregnancy: Not studied. Avoid during pregnancy.
Clinical Details
Compare With Similar Peptides
Semax is stimulating/focusing. Selank is calming/anxiolytic. Complementary pair — often used together as 'Selank + Semax stack.'
Selank
A Russian-developed synthetic peptide that reduces anxiety and supports immune function — based on the body's natural tuftsin molecule.
Dihexa
A potent cognitive peptide that promotes new brain connections — millions of times more potent than BDNF at stimulating neural growth.
Frequently Asked Questions
This compound is in early research stages. We do not currently offer it.
Looking for something similar? See what we offer for Cognitive.
This compound is in early research stages. It has not been FDA-approved and may not be available through compounding pharmacies. The information below is for educational purposes only. Do not attempt to self-administer research compounds.