Thymosin Beta-4 (TB-500)
THY-moh-sin beta four / T-B five hundred
A tissue repair peptide found throughout your body — promotes healing of muscle, tendon, and connective tissue injuries.
Also known as: TB-500, TB4, Tβ4
Last reviewed: April 2026
What It Does
Thymosin Beta-4 is a naturally occurring 43-amino-acid peptide present in virtually all tissues. It plays a central role in tissue repair by promoting cell migration, blood vessel formation, and reducing inflammation. TB-500 is the synthetic version used in research and clinical applications.
Why People Take It
How It's Administered
Subcutaneous Injection
Injection near injury site or into belly fat
Frequency
2 times per week during loading, then weekly
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
2.5mg – 5mg per injection
What To Expect
Week 1–2
Reduced inflammation at injury sites.
Month 1
Noticeable healing acceleration. Improved mobility.
Month 2–3
Significant tissue repair. Many complete protocol.
Side Effects
Overall: Mild
Common (1–10%)
Injection site reaction
Brief discomfort at site.
Uncommon (0.1–1%)
Headache
Transient.
Who Should NOT Take This
• Active cancer (promotes angiogenesis)
• Pregnancy
Drug Interactions
• Anticoagulants — theoretical interaction
Pregnancy: Not studied. Avoid during pregnancy.
Clinical Details
Compare With Similar Peptides
Both promote tissue healing. BPC-157 is more GI/tendon-focused with more research data. TB-500 has broader tissue distribution. Often used together.
Open Full Comparison Tool →Frequently Asked Questions
This compound is in early research stages. We do not currently offer it.
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This compound is in early research stages. It has not been FDA-approved and may not be available through compounding pharmacies. The information below is for educational purposes only. Do not attempt to self-administer research compounds.